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The NICE clinical guideline on the identification, assessment and management of obesity recognises GLP-1 receptor agonists, including semaglutide, as clinically appropriate interventions for adults who meet the relevant eligibility criteria, and emphasises that clinical outcomes are achieved when treatment is delivered as intended including strict adherence to administration protocols such as the fasted dosing requirement

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By contrast, other GLP-1 drugs such as exenatide and dulaglutide did not show similarly strong reductions in mental-illness risk in the summarized reporting