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Liraglutide shares 97% sequence homology with human GLP-1 and can bind to and activate GLP-1R

However, the beneficial effects of GLP1 were limited in clinical trials of type 2 diabetic patients due to the very short halflife of GLP1, which is approximately 25 min, via degradation by the enzyme dipeptidyl peptidase 4 (DPP4) (Holst, 2019

Semaglutide 24 mg once weekly in patients with non-alcoholic steatohepatitis-related cirrhosis: a randomised, placebo-controlled phase 2 trial

These findings should be confirmed in a large representative sample

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