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If you are currently taking Ozempic to lose weight, you may benefit from switching to Wegovy, as it is available in higher doses

GI side effects A recent systematic review of 39 randomized controlled trials of GLP-1RAs showed a class effect of increased risks of nausea, vomiting, diarrhea and constipation compared with placebo (15) in individuals without diabetes

3.1 Brain insulin resistance Insulin resistance in the brain perpetuates neuroinflammation, tau hyperphosphorylation, and amyloid pathology in AD and is therefore a driver of neurodegenerative disease (Hlscher, 2019)

However, BMI remained unchanged, indicating that the intracranial pressure effect was likely a direct action of exenatide rather than weight loss alone

Note: These are guideline-based indications at a population level

12,13 GLP-1 RAs are recommended in the treatment guidelines by the American Diabetes Association as well as the American Association of Clinical Endocrinology (AACE) Consensus Statement & European Society of Cardiology for type 2 diabetes mellitus patients with co-morbidities, like established atherosclerotic cardiovascular disease and obesity