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With over 42% of adults in the United States classified as obese, finding effective weight loss solutions is more important than ever

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In the largest pharmacogenomics GWAS of GLP-1 medications to date (15,237 participants, replicated in the All of Us cohort), researchers identified a missense variant in GLP1R the gene encoding the very receptor that semaglutide and tirzepatide bind that significantly predicts how much weight a person loses on treatment

Tirzepatide activates two hormone pathways to lower blood sugar and support weight loss in prediabetes

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But they're also real medications with real risks that benefit substantially from proper medical supervision