contraindications for glp-1 agonists include Does Help Lower Cholesterol? Effects and Clinical Use GLP-1 Receptor Agonists | New
Description
The pooled outcomes for tirzepatide showed a more significant positive impact in each individual lipid measure as compared to semaglutide in a population with similar baseline characteristics

Lancet 394 , 121130 (2019)

doi: 10.1056/NEJMOA1603827 37 LeRNguyenMTAllahwalaMAPsaltisJPMaratheCSMaratheJAet al

Effects of GLP-1 on gastric emptying, antropyloric motility, and transpyloric flow in response to a nonnutrient liquid

But the caveat always caveats
If retatrutide follows the typical regulatory pathway, a first approval for obesity could arrive in 2026 or 2027