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Two structural modifications give it the long plasma half-life that distinguishes it from native GLP-1: an aminoisobutyric acid (Aib) substitution at position 8 (which blocks DPP-4 enzymatic cleavage) and a fatty di-acid chain attached at lysine-26 (which drives reversible albumin binding)

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Semaglutide's longer half-life already produces relatively stable levels on a weekly schedule, so splitting provides less pharmacokinetic benefit

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For example, in fast-growing markets like China, foreign buyers are signing licensing deals because they do not require the same lengthy approvals as full-blown M&A deals