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A major 2025 analysis published in JAMA Network Open followed more than 60,000 adults with obesity and type 2 diabetes

Treatment With Recombinant Human Insulin-Like Growth Factor (rhIGF)-I/rhIGF Binding Protein-3 Complex Improves Metabolic Control in Subjects With Severe Insulin Resistance

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Psychopharmacology (Berl) 2006;186:402413

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Although depression is not a common side effect, nor a long-term side effect of Mounjaro, it has been mentioned in some reports