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Included animals were then randomized into treatment groups based on mean baseline PSR area% 1 week before dose start

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4.2 Lipid regulation Tirzepatide has demonstrated efficacy in improving lipid profiles through GIP receptor activation, which increases the lipid buffering capacity of fatty tissue, facilitating triglyceride clearance and reducing ectopic fat accumulation

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Consistent with this, GIP promotes clearance of circulating TAGs in dogs (168) and enhances adipose tissue TAG accumulation in rats (169) and humans (170)
