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For weight management, continuation follows specific NICE guidance and local specialist service protocols, typically with defined treatment durations

The difference between Exendin-4 and Exenatide lies primarily in the replacement of Ala with Valine (Val) at the 19th position and Asn with aspartic acid at the 28th position in Exendin-4

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Most of these visits (69.3%) were due to severe gastrointestinal adverse reactions

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Cost-effectiveness and health economic implications The elevated cost of acquisition of GLP-1 receptor agonists convey major challenges for healthcare systems, with yearly treatment expenses between $10,000 and $15,000 USD, markedly surpassing those of conventional diabetic drugs (Kong et al