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This occurs through two main pathways: (1) FXR induces a small heterodimer partner that represses CYP7A1 and CYP8B1 by inhibiting hepatocyte nuclear factor 4 and liver receptor homolog 1
Matsueda K, Hongo M, Tack J, Saito Y, Kato H
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, Madara, J
The effect of linagliptin on glycaemic control and tolerability in patients with type 2 diabetes mellitus: A systematic review and meta-analysis
