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even the cost of the drug theyre on

While these concerns are valid, microdosing outside of clinical guidance is not a safe or evidence-based workaround

Slower titration schedules often reduce gastrointestinal burden, while maintenance-phase diarrhea suggests either dose tolerance or need for formulation adjustment

In addition to the direct nephroprotective effect, GLP-1R agonists have indirect protective effects as they decrease the incidence of many risk factors associated with kidney injury

Do I still need metformin after starting a GLP-1 injection

Other effects of GLP-1 include inhibiting gastric emptying, decreasing food intake, and decreasing glucagon secretion resulting in a decrease in endogenous glucose production [7,8,9]