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The specific criteria for inclusion and exclusion of relevant studies in terms of PI(E)COS (Population, Intervention/Exposure, Comparison, Outcomes, and Study design) are provided in Table 1

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Cardiovascular protection: Some GLP-1 medications have been shown to reduce the risk of major cardiovascular events such as heart attack, stroke, and cardiovascular death in people with type 2 diabetes, particularly those with existing cardiovascular disease or multiple risk factors