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Researchers emphasized that the findings do not establish causation

DISCUSSION The findings of our meta-analysis provide robust evidence for the efficacy and safety of the triple-hormone-receptor agonist retatrutide in obesity treatment

Furthermore, compelling evidence implicates this local, brainstem-derived GLP-1, rather than gut-derived GLP-1, as a principal modulator of physiological GLP-1R dependent signals that regulate appetite and body weight (Drucker and Asa, 1988

Kushner, M.D
