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Leptin-regulated endocannabinoids are involved in maintaining food intake

The goal is not the fastest possible drop on the scale

In this absence of therapeutic advances, the proliferation of societal factors that promote weight gain has left the United States with a 41.9% prevalence of obesity and a 73.9% prevalence of overweight or obesity among its adult population, according to the National Center for Health Statistics

Doses range from 150mg to a maximum of 450mg per day, though most prescribers keep patients at 300mg daily as the standard therapeutic dose

Scientific References Frequently Asked Questions Why am I craving sugar on Wegovy

And to be perfectly fair to Kailera, I think the 4mg dose is probably the best dose in terms of blending weight loss with manageable side effects