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First, unlike in humans, this dose did not induce significant weight loss in our hyperphagic ZSF1 rats over the 16-week study period, a critical observation that sets the foundation for our investigation

Gradual Titration Strategy Smaller stepwise adjustments can reduce GI side effects and improve real-world adherence over the first months of therapy

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doi: 10.1186/s12933-023-02065-2

Semaglutide has yielded even greater benefits, with its maximal dosage over 72 weeks increasing the rate of MASH resolution without fibrosis progression (59% vs