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In a recent randomized trial, one year of combined GLP-1 therapy with exercise training preserved bone mineral density, while GLP-1 therapy alone decreased bone mineral density [162]
Hence, GLP-1s as a class were not considered to modify the natural history of the disease as they were not anti-fibrotics. In 2024, this perception was challenged as the dual agonists tirzepatide (Mounjaro/Zepbound, Eli Lilly
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Aizkavt diabta nefroptijas progresanu un palnint eGFR samazinans trumu par 30% (FLOW tests)
8.4%, p=0.61)
N Engl J Med 2021;385:896907
