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The dosage is carefully escalated over time to improve tolerability and reduce the risk of gastrointestinal side effects

Recently, increasing evidence indicates that functional autophagy is required for synaptic functions, including neurotransmission and synaptic plasticity (75)
These data also raise the possibility of tissue GLP-1 resistance as a key factor underlying the failure to improve lipid tolerance in mouse models characterized by reduced DPP-4 activity, elevated levels of GLP-1, and yet normal or deteriorated lipid tolerance

Cosmas, Silas Kiruki, Olivia A
The wave of launches marks a pivotal shift for Indias nascent GLP-1 market, where high prices had until now limited access despite surging global demand for the therapy
McGill et al., Long-Term Efficacy and Safety of Linagliptin in Patients With Type 2 Diabetes and Severe Renal Impairment, Diabetes Care, vol