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This guide focuses on practical food choices and timing that many people find supportive as fullness cues stabilize

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In comparison to sitagliptin, semaglutide has been shown to significantly reduce the 12-month risk of cognitive deficits, dementia, and epilepsy.[63] In PCOS, a meta-analysis indicated that exenatide and liraglutide exhibit stronger effects on insulin sensitivity and BMI reduction than metformin.[71] A 24-week study found that exenatide led to a significantly higher rate of spontaneous pregnancies and more regular menstrual cycles compared to metformin.[72] Although rapid weight loss in some contexts is associated with an increased risk of frailty fractures, GLP-1RAs may mitigate this effect.[73, 74] Both exenatide and dulaglutide were found to increase bone mineral density, while lixisenatide and liraglutide were associated with a reduced risk of fractures, suggesting differential effects of GLP-1RAs on bone metabolism.[74] OTHER CONSIDERATIONS Side effects and adverse events related to GLP1-RAs While GLP-1RAs are credited with a growing list of health benefits, they have also been associated with a wide variety of adverse effects that may vary among agents.[6, 21] Common side effects include nausea, vomiting, diarrhea, mild tachycardia, and injection site reactions.[75] A pooled analysis of 33 clinical trials (n=13,548) found an increased risk of treatment discontinuation due to gastrointestinal effects such as nausea and vomiting.[6] Potential adverse events include pancreatitis, cholelithiasis, and dehydration.[76] Rodent studies and one observational study in humans have raised concerns about GLP-1RAs impact on thyroid cancer risk

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Thats not how GLP-1s work

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All GLP analogs were subcutaneous injectables until the arrival of Rybelsus (oral semaglutide) in 2020

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But a growing body of research, and a wave of real-world experience, suggests these drugs may have meaningful benefits for people with T1D too: lower daily insulin doses, flatter glucose curves on your CGM, and potentially better long-term protection for your heart and kidneys

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Given the limited published data on GLP-1 use in GDM, this platform provided the most relevant and up-to-date information, including ongoing studies with detailed protocols not yet available in peer-reviewed literature

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