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The STEP 1 extension study showed approximately two-thirds of weight was regained within one year of stopping semaglutide
Headaches (moderately worse) GLP-1 related headaches combined with alcohol-induced dehydration headaches create a compounding effect

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(2023) Obese patients taking antidepressants lost weight on semaglutide
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But nutritional support can minimize the severity and accelerate recovery
