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This is a good checkpoint for assessing whether to continue the current protocol, adjust doses, or add complementary compounds

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There were no significant difference in the expression of SESN2, LC3II and p62 among siSESN2, siSESN2 + PA and siSESN2 + PA + liraglutide groups

Declarations Acknowledgement None

Diabetes Type 1 diabetes is caused by autoimmune-mediated destruction of pancreatic beta-cells [33], and type 2 diabetes is caused by both insulin resistance and relative deficiency of insulin [3436]

These results translated to significant proportions of participants achieving clinically meaningful weight loss: 5% or More Weight Reduction: 92% (4 mg), 100% (8 mg), 100% (12 mg), and 27% (placebo) 10% or More Weight Reduction: 75% (4 mg), 91% (8 mg), 93% (12 mg), and 9% (placebo) 15% or More Weight Reduction: 60% (4 mg), 75% (8 mg), 83% (12 mg), and 2% (placebo) These data underscore retatrutides potential to deliver unprecedented weight loss in a significant portion of individuals with obesity