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Shorter-acting agents may exert more pronounced effects on postprandial glucose through transient gastric emptying delay, while longer-acting agents may provide steadier effects on fasting and overall glycemic patterns

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doi: 10.1016/j.cmet.2018.03.001

These findings strongly indicate that all three drugs are effective in reducing food intake and promoting weight loss, with retatrutide demonstrating the most significant impact

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Clinical trial data from FDA-approved labeling typically report gastrointestinal adverse effects broadly, with nausea occurring in 1544% of patients depending on the specific agent and dose, while vomiting affects 524% of users