glp 1 agonist eli lilly is now pharma's top revenue company. It just got FDA approval for an oral GLP-1, but Wall Street isn't celebrating Lilly launches GLP-1 pill, kicking

Journal reference: Cesta, C

Deactivation Mechanism of Glucagon-like Peptide-1/2 by Dipeptidyl Peptidase 4 Intestinal L-cells and K-cells release the physiologically active forms of GLP-1 and GIP, known as active GLP-1 amide and GIP, in response to oral glucose via increased cAMP (69)

The core issue is straightforward

News about GLP-1RA agonists has infiltrated social media outlets, and is being spoken about by celebrities, fashion models and influencers," said Emma Cooper, MD, a resident physician in the Department of Psychiatry & Human Behavior at UCI School of Medicine

However, GLP1R agonists produce a variety of effects in the brain as well, making efforts to increase the ability of such drugs to cross the blood-brain barrier of high interest

GLP-1s impacts reducing inflammation and promoting cellular survival extends into the musculoskeletal system: protecting chondrocytes, inhibiting their apoptosis, influencing the composition of cartilage and maintaining synovial fluid homeostasis