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GIP at 20 nM had no major effect on adipogenic gene expression, while 10 nM Tirzepatide reduced insulin receptor (INSR) and ADIPOQ levels

According to the Breakthrough Prize committee, these five scientists' complementary contributions from basic hormone discovery through physiological understanding to pharmaceutical development have led to highly effective drugs for diabetes and obesity, ushering in a new era of GLP-1 medicines for cardiometabolic disorders

Emerging GLP-1 benefits being studied Newer research suggests GLP-1 drugs may have effects beyond blood sugar control, appetite and weight loss

4 GLP-1 receptor agonists and suicidality Semaglutide, dulaglutide, liraglutide, exenatide, and tirzepatide are administered daily or weekly, either by injection or in tablet form, with limited approval for children over 10 or 12 years of age, or only adults, for T2DM or weight reduction, offering additional benefits for the heart and kidneys

In: Textbook of Gastroentelogy

Seek immediate medical attention if you experience unusual symptoms, including shortness of breath, swelling, or severe abdominal pain