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Patients who had larger body mass indexes BMIs greater than 35 lost even more weight, successfully shedding 85 pounds or 30.3% of their body weight after about two years

Lien et al., 2014)

The difference was about 3 to 4 additional cases per 10,000 patients over 18 months , with the apparent excess risk more concentrated in older adults, men, and people with more advanced diabetes or existing eye or cardiovascular conditions

That decision is made carefully

The Dosage Clinical trials used various doses, with the 12 mg dose providing the biggest impact

However, the norgestrel Cmax was reduced by about 30% and Tmax was delayed by 45 minutes