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GLP-1 (Glucagon-like peptide-1) plays a crucial role in managing blood sugar levels, reducing appetite, and supporting weight loss by influencing insulin and glucagon production.

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Purpose of Review This review provides a comprehensive and scholarly examination of glucagon-like peptide-1 receptor (GLP-1R) agonists, tracing their evolution from glycemic control agents in diabetes mellitus (DM) to multifaceted therapeutics with expanding indications in cardiovascular, renal, and metabolic health

In DIO mice treated with Semaglutide, weight loss attenuated, and body weight was maintained at a constant level after 2 weeks