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Understanding these mechanisms is key to understanding the semaglutide vs tirzepatide comparison UK clinicians use to guide patients

Gastrointestinal symptoms are the most frequently reported adverse effects and include nausea, diarrhoea, vomiting, constipation, abdominal pain, and dyspepsia (indigestion)

Women who become pregnant or are planning pregnancy should discuss tirzepatide use with their healthcare provider, as the medication is not recommended during pregnancy

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This mechanism has implications for the estimated 100 million Americans with fatty liver disease, many of whom have no effective pharmacological treatment options

Nat Med 28 , 450451 (2022)
