is there a pill version of semaglutide The FDA approved the GLP-1 receptor agonist (Wegovy), making it the first oral GLP-1 agent indicated for weight loss, Novo Nordisk announced on Monday. The once-daily 25 Wegovy® Pill Guide and Dosing

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Aging is characterized by a progressive decline in physiological function, an increased risk of chronic diseases, and multiple molecular and cellular alterations, including inflammation, oxidative stress, and mitochondrial dysfunction

In the largest pharmacogenomics GWAS of GLP-1 medications to date (15,237 participants, replicated in the All of Us cohort), researchers identified a missense variant in GLP1R the gene encoding the very receptor that semaglutide and tirzepatide bind that significantly predicts how much weight a person loses on treatment

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Clinical takeaway: Assess response and tolerability every 4 weeksdont reflexively push to the next standard dose