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Studies show GLP-1-only agonists (like semaglutide) produce 15-17% weight loss at maximum doses, making it the foundation of the triple-agonist effect

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[12] [13] Pharmacological options are more limited, with NICE advising caution: Antidepressants : A course of duloxetine, amitriptyline, citalopram, or other antidepressants may be considered after discussion of potential benefits and harms