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doi: 10.1038/mp.2017.91 [e-pub ahead of print 2 May 2017]

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These estimates are based on individuals younger than 60

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These results suggest that maintaining both iNAMPT-mediated NAD + biosynthesis in major metabolic organs and plasma eNAMPT, a key effector of adipose-to-brain signaling, by boosting adipocyte iNAMPT-mediated NAD + biosynthesis could improve organ function and whole-body glucose metabolism and promote a healthy physical and mental status