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Nevertheless, GIP secretion is not enhanced in individuals with T2D treated with glibenclamide [43], indicating that the contribution of K ATP channels to GIP secretion in vivo , especially in humans, is minimal

Mitochondrial dysfunction has negative effects on the body and is believed to be an important factor in aging and disease

doi: 10.1161/hh1701.095716

Conversely, those with milder hyperglycaemia might see quicker stabilisation but smaller absolute reductions

Given all these unknowns, it may be best for Congress to pump the brakes on expanding GLP-1s in Medicare before we have a better understanding of their full value and a way to pay for it.

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