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Primary care doctors can assess drinking habits and provide resources for those struggling with alcohol use

Participants who received the three different doses all lost more weight than a placebo group, which lost an average of more than 2% of body weight

If orforglipron can be manufactured at scale for a fraction of the cost of injectable alternatives, and if its oral format eliminates the injection barriers that prevent millions from starting therapy, the public health impact could be measured in reduced cardiovascular events, fewer diabetes-related amputations, decreased obesity-related cancer incidence, and extended healthy lifespan across populations

Endocrinology (2007) 149(2):5749

The authors noted this is an off-label strategy and called for controlled trials to validate effectiveness and define who might benefit

For example, if you typically inject in your abdomen, consider switching to your thigh