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However, in stark contrast to SYGL-1 and LST-1, Ascl2 and LgR5 functions are not independent of niche signaling: LgR5 enhances Wnt signaling and Ascl2 works with Wnt-dependent transcription factors to induce a stem cell transcriptional signature [53]

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Blood glucose levels should be monitored, and the reduction of existing blood glucose-lowering drugs should be considered

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