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However, the current evidence base remains limited

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Preclinical studies showed that exendin-4, a GLP-1R agonist derived from the saliva of the Gila monster, was able to significantly reduce the hepatic accumulation of triglycerides both in mouse models [82] and in human hepatocytes [83] by activating the signaling cascade downstream of the insulin receptor (see below)

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GLP-1 crosses the blood-brain barrier in limited amounts, but the brain also produces its own GLP-1 through neurons in the nucleus tractus solitarius (NTS) of the brainstem

The aluminum frames are lightweight, and the tires are a bit thicker than 2 inches, which is best for riding on sand