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The array sensitivity analysis showed that an unmeasured confounder would again need to have at least 15% imbalance and a confounder-outcome association of 3.5 or 30% imbalance and a confounder-outcome association of 2.0 to bias results by 25% or more (supplementary figure S3B)

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Dual Agonist Unlike treatments that focus on a single hormone, tirzepatide activates both GLP-1 and GIP receptors

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A narrative review of 10 primary studies that assessed energy intakes in GLP-1 RA users revealed that total calorie intake was reduced by 16 to 39% in a single meal 25

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Preclinical and translational studies provide plausible explanations for these observed cardiovascular effects

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Blood Pressure-Lowering Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists

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Large cardiovascular outcome trials involving tens of thousands of patientssuch as LEADER (liraglutide), SUSTAIN-6 (semaglutide), and REWIND (dulaglutide)have not demonstrated an increased incidence of medullary thyroid carcinoma or other thyroid malignancies compared to placebo groups

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