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these experiments also showed that although glucose production was inhibited initially, plasma glucose concentrations only fell by 0.51.0 mmol/L in spite of prolonged infusion, because the insulinotropic effect of GLP-1 disappeared as glucose concentrations fell, demonstrating the glucose dependency of these actions

Perlas A, Chan VW, Lupu CM, Mitsakakis N, Hanbidge A

During the full time period (2018 2024), 69.4% of GLP-1 RA prescriptions had a dispense within 60 days of their prescription (e.g., were initiated within 60 days)

The survey results indicate that adoption (of GLP-1 drugs) will be rapid and long-lasting, Ey said in its report

doi: 10.1146/annurev-pharmtox-010510-100540 [DOI] [PubMed] [Google Scholar]

The peptide cycle planning guide covers different strategies for managing long-term use