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If appropriate, the clinician prescribes a GLP-1 option, such as weekly Semaglutide injections, Tirzepatide injections, or oral GLP-1 drops, with dosing and a titration plan

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Retatrutide adds glucagon activation on top of that

Use of liraglutide 3mg daily in patients with obesity without diabetes was associated with nausea in 40.2% compared to 14.7% in the placebo (68)