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As a dual GCG/GLP-1 receptor agonist weight loss drug, mazdutide can deliver significant weight loss efficacy and metabolic benefits such as waist circumstance and liver fat content reductions to adults with overweight or obesity

doi: 10.1016/j.neuroscience.2011.02.023 84 FortinSMChenJCPetticordMCRagozzinoFJPetersJHHayesMR

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When tested in pancreatectomised dogs the first fraction stimulated secretion from the pancreas while the second seemed to lower blood glucose without activating secretion from the pancreas