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Semaglutide is a GLP-1 receptor agonist that helps regulate blood sugar and appetite

Direct-to-consumer prescription companies like Hims & Hers (public) and Ro (Series E) have expanded their offerings to include GLP-1s amidst rising popularity of the drugs

Be aware of digestive side effects Some people experience nausea, bloating, constipation, diarrhea or heartburn when starting these medications

93 GLP-1 stimulates insulin secretion in a glucose-dependent manner, decreases pancreatic glucagon secretion, increases -cell mass and insulin gene expression, stimulates satiety in the brain, and increases peripheral insulin sensitivity

Liu Y, Liu H, Li C, Ma C, Ge W

Severe, unrelenting nausea can signal that your current dose or dosing frequency is too aggressive for your individual physiology and may benefit from adjustment