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[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Bariya S.H., Gohel M.C., Mehta T.A., Sharma O.P

Strategies for managing plateaus include: Verify medication adherence and proper injection technique Reassess dietary intake, as reduced appetite may normalize over time Increase structured physical activity with emphasis on resistance training Consider dose optimization if the patient is not yet at the maximum approved dose Evaluate for addition of a complementary medication (phentermine, naltrexone/bupropion, or topiramate) Reframe expectations: weight maintenance at a lower body weight is itself a significant clinical success Clinical Training and Certification The complexity of prescribing incretin-based medications for obesity demands formal clinical education beyond what most providers receive in residency or advanced practice training

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2025 (Diabetes Care) confirm 14% fewer MACE, 13% fewer CV deaths, 12% fewer all-cause deaths, 9% fewer heart-failure hospitalizations, and 17% fewer renal composites with GLP-1RA [39, 40]

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Potential Benefits & Side Effects What controlled trials of the branded CagriSema pharmaceutical describe
