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Additionally, the Ala at the 8th position is substituted with Gly, and the Arg at the 34th position is replaced by Lys (Fig

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Consistently, many experimental studies revealed that a dual GIP/GLP-1 receptor agonist DA4-JC has a neuroprotective effect against AD neuropathology by regulating the PI3 K/AKT/GSK3 signaling pathway in AD mouse model (Maskery et al
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