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Heart Failure HF and its specific subtype HFpEF represent two significant therapeutic areas where GLP-1 agonists are being developed

Recent evidence suggests that CD36-mediated metabolic reprogramming is associated with resistance to HER2-targeted treatments in addition to oestrogen-driven mechanisms, thereby allowing cancer cells to circumvent treatment

Successful weight management is not about chasing rapid results

Poly(ADP-ribose) synthase is the major endogenous nonhistone acceptor for poly(ADP-ribose) in alkylated rat hepatoma cells

A NOVEL study has shown that Glucagon-like peptide-1 (GLP-1) agonists, medications widely used for obesity and type 2 diabetes, may offer benefits for patients with hidradenitis suppurativa (HS), a chronic inflammatory skin condition often associated with obesity

De Vadder F, Kovatcheva-Datchary P, Goncalves D et al (2014) Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits