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Medical conditions such as polycystic ovary syndrome (PCOS), Cushing's syndrome, or hypothyroidism may also impede progress and warrant evaluation if suspected

People with sensitive skin should avoid skin irritation by patch-testing first or avoiding these products entirely

It is therefore implausible that short-term GLP-1 RA exposure alone would initiate de novo malignancy within a 1-year timeframe, particularly when considering even shorter exposure periods

Activation of GLP-1 receptors has been shown to exert direct anti-inflammatory effects, potentially by inhibiting the activation of hepatic stellate cells and reducing the production of pro-inflammatory cytokines (6)

Understanding these factors helps ensure safe, effective management of both diabetes and mental health conditions

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