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Start tirzepatide at 2.5 mg weekly immediately after the last dose of semaglutide 2.4 mg, without any washout period, then titrate monthly to 5 mg, 7.5 mg, 1...

This review summarizes comparative evidence for providers who are determining which of the two classes may be the most appropriate for a specific patient

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Cardiovascular System: While the exact mechanisms are not fully elucidated, semaglutide appears to have direct and indirect effects on the cardiovascular system