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69 However, these findings have not been confirmed in subsequent large-scale RCTs

Can J Biochem

45,46 Oral semaglutide was further investigated against placebo with regard to its cardiovascular safety (PIONEER 6) in patients considered to be at high cardiovascular risk, safety and efficacy in patients with moderate renal impairment (PIONEER 5), and safety and efficacy as an add-on therapy to insulin-treated patients (PIONEER 8)

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Ongoing Clinical Trials Several ongoing clinical trials aim to evaluate the effect of GLP-1RAs treatment with paired histological evaluation (Table 3)