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Milder et al

The American Diabetes Association and American College of Physicians recommend individualized therapy

In the United Kingdom, the primary mechanism for reporting suspected adverse drug reactions outside of a clinical trial is the MHRA Yellow Card Scheme , accessible online at yellowcard.mhra.gov.uk

With continued research and collaboration between academia, industry, and clinicians, GLP-1based interventions have the potential to address complex metabolic diseases more comprehensively, shaping the next generation of treatments and improving outcomes for patients worldwide

These benefits must be balanced with their impact on the gut microbiome, as many patients significantly alter their dietary patterns under the influence of these medications

For example, while GLP-1 RAs carry a low intrinsic risk of hypoglycemia, the addition of a GLP-1 RA to background sulfonylurea or insulin therapy can increase the risk for treatment-emergent hypoglycemia