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Practical approach to SGLT2 inhibitors for treatment of cardiovascular disease

Even though GLP-1 medications may increase heart rate slightly, theres no evidence that they increase the risk of arrhythmias (irregular heart rhythms)

Contraindications include personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, active pancreatitis, severe diabetic retinopathy, and certain pregnancy circumstances

Studies show that roughly 2740% of new prescriptions (across categories) are abandoned before pickup ( [9] ), and GLP-1 class fill rates are similarly challenged

Varies by plan

This is distinct from the appetite-suppressing effect of GLP-1 and GIP