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Consistent with a role of vagal afferents and vagal afferent GLP-1 receptors in the eating-inhibitory effect of peripheral endogenous GLP-1, virus-mediated knockdown of GLP-1R in vagal afferent neurons increased meal size, accelerated gastric emptying, and reduced prandial insulin secretion in rats, while not affecting 24 h food intake or body weight [518]

10.1016/j.endmts.2025.100228 Endocr Metab Sci

M.ReimannF.SkibickaK

And, continuous yo-yo dieting has led to an even more unhealthy relationship with food

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Some patients may worry that the drug can cause gastrointestinal cancers but Dr