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Recently, a phase II multicentre, double-blind, randomized controlled trial including 338 adults with obesity were administered retatrutide (1, 2 mg starting dose increased to 4, 2 mg starting dose increased to 8, 2 mg starting dose increased to 12 mg) compared to placebo over 48 weeks [64]

Funding This work was supported by Statutory Funds of the Laboratory of Immunoendocrinology, Maj Institute of Pharmacology, Cracow, Poland

3.9% (obesity) Pregnancy loss higher in all groups with metabolic risk (2329%) Live birth rate: 59% (GLP-1 RA group) Conclusion: Reassuring data with no signal for increased congenital malformations

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Researchers identified adults who used GLP-1 receptor agonists and DPP-IV inhibitors and obtained the duration of use in the 6 years before the lag time

Specifically, treatment with exenatide acetate increased the ratio of p -AMPKThr172/AMPK, inhibited NF-B p65 phosphorylation, and downregulated pro-inflammatory markers, including IL-1 and TNF- [69]