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3.3 Metabolic modulation and immunomodulatory effects The close relationship between BMI, metabolic dysfunction, and immune activation has important implications for the potential use of GLP-1Ras in obese patients with PsA

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Lactobacillus Reuteri Lactobacillus reuteri has been linked to increased GLP-1 secretion and improved gut health

Kaur et al

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Subsequently, secondary bile acids, key signaling molecules produced by bile acids and gut microbiota metabolism, are bound to membrane receptors (Takeda G protein-coupled receptor 5, TGR5/G protein-coupled bile acid receptor 1, GPBAR1) and nuclear receptors (Farnesoid X Receptor, FXR), which stimulates colonic secretion of GLP-1 and PYY