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Description
Some people are not suitable for GLP-1 therapy, including people who are pregnant or breastfeeding and people with certain gastrointestinal conditions
The two types of incretin hormones that have critical roles in incretin signaling, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), bind to specific members of the G-protein-coupled receptor (GPCR) family: the GLP-1 receptor (GLP-1R) and the GIP receptor (GIPR), respectively
It ensures that your body adapts slowly, reducing the risk of side effects and improving long-term tolerability
This situation is reversed in people with T2D where, although GIP secretion remains largely intact, GIP receptor activity is much reduced
May your titration stay gradual, your side effects stay mild, and your protocols stay evidence-based.
Bariatric surgery often requires BMI 40 or greater, or BMI 35 or greater with serious obesity-related conditions
